Government and Politics
- Robert J. Dole (Gamma-Omicron), Former Senator, Kansas (1969-1996); 1996 Republican Party Presidential Nominee.
- Sonny Perdue (Beta-Lambda), Governor of Georgia (2003-)
- Richard Burr (Delta Omega), Senator, North Carolina (2005-); former Congressman, North Carolina (1992-2002)
- John Murtha (Beta-Delta), Congressman, Pennsylvania (1974-)
- Vic Snyder (Theta-Delta), Congressman, Arkansas(1997)
- Dustin McDaniel (Xi), Arkansas Attorney General (2007-)
- Jefferson Davis (Xi), President of the Confederate States of America. Honorarily inducted into the fraternity following his son's death.
- Dwight Green (Alpha-Pi), Former Governor of Illinois (1941-1949)
- Lee S. Dreyfus (Beta-Epsilon), Former Governor of Wisconsin (1979-1983)
- David C. Treen (Sigma), Former Governor of Louisiana (1980-1984)
- Paul Patton (Beta-Nu), Former Governor of Kentucky (1995-2003)
- Beauford H. Jester (Tau), Former Governor of Texas (1947-1949)
- Estes Kefauver (Lambda), Former Senator, Tennessee (1949-1963)
- John G. Tower (Iota), Former Senator, Texas (1961-1985)
- Paul J. Fannin (Gamma-Rho), Former Senator, Arizona (1959-1987)
- Joe D. Waggonner (Epsilon-Gamma), Former Congressman, Louisiana (1961-1978); former Chairman of House Ways and Means Committee.
- Dante Fascell (Epsilon-Beta), Former Congressman, Florida (1955-1993)
- John Ehrlichman (Delta-Nu), Counsel and Assistant to the President for Domestic Affairs under President
- Richard Nixon
- Larry M. Speakes (Delta-Xi), Press Secretary for President Ronald Reagan.
- Martin C. Petersen (Rho), Former Deputy Executive Director of the Central Intelligence Agency
- David E. Kendall (Alpha-Pi), Attorney to President Bill Clinton
Entertainers
Greg Raymer (Beta-Chi), winner World Series of Poker Jimmy Buffett (Epsilon-Nu), singer - Gordon Jump (Gamma-Chi), actor, WKRP, Maytag Man
- Dennis Haskins (Alpha-Iota), actor, Saved By the Bell
- Robert Redford (Gamma-Tau), Oscar-winning actor, Founder of Sundance Festival
- John Lydon (Rho), musician, entertainer
- David Nelson (Delta-Eta), Actor, Ozzie and Harriet
- Mort Walker (Beta-Gamma), cartoonist, Beetle Bailey
- Josh Kelley (Delta-Xi), musician
- Kevin Griffin (Gamma), lead singer/ musician, Better Than Ezra
- Chris Harrison (Theta-Psi), actor, The Bachelor
- Mike O'Malley (Beta-Kappa), actor, 'Yes Dear', Guts
- Hoagy Carmichael (Beta-Theta), composer and movie star
- Gailard Sartain (Epsilon-Mu), Actor/Comedian/Visual Artist/Writer
- Bobby Pulido (Lambda-Psi)musician, Tejano recording artist
- Wink Martindale (Epsilon-Pi), TV game show host
- Michael C. Williams (Xi-Gamma), actor 'The Blair Witch Project
- Andrew Daniel (Theta-Upsilon), winner Big Brother 5, model
- Oroku Saki, (Xi-Gamma), Entertainer
- Paul "P.H." Naffah (Rho), drummer The Refreshments, Roger Clyne and the Peacemakers
- John Driscoll (Kappa Phi), actor, Guiding Light
- Whisperin Bill Anderson (Beta Lambda), Country Music Singer and Songwriter
Business
- Craig Barrett (Beta-Zeta), Chairman and former CEO, Intel
- Ted Turner (Beta-Alpha), media mogul (TNT,TBS,CNN,Atlanta Braves)
- Todd Wagner (Beta-Theta), Broadcast.com co-founder
- Albert Bond Lambert (Zeta), Early Aviator, Sponsor of the The Spirit of St. Louis, namesake of Lambert International Airport
- Robert Eaton (Gamma-Omicron), Former Chairman DaimlerChrysler AG
- Alan Mulally (Gamma-Omicron), President and CEO Ford Motor Company
- Russell Wiener (Phi) Co-founder Donruss Baseball Cards
- William R. Johnston (Mu), former President NYSE
- Mike Eskew (Chi), CEO, UPS
- William Hewlett (Beta-Zeta), founder, Hewlett Packard
- Gary Forsee (Beta-Chi), President and CEO of Sprint Nextel
- Howard Hyle (Nu), Former Vice President of Coca-Cola
- Gordon Binder (Chi), Former CEO of AMGen
- Charles Schneider (Lambda-Upsilon), Sommelier, Restauranteur
- Cyrus R. Smith (Tau), Former President of American Airlines
- Willard F. Rockwell (Alpha-Delta), Founder of Rockwell International
- Richard Rainwater (Epsilon-Delta), Financeer
- Ben Gilmer (Beta-Eta), CEO, AT&T
- R.W. Lundgren (Gamma-Sigma), Chairman of the Board, Dow Chemical
- Allen Jacobson (Gamma-Lambda), CEO, 3M Company
- Dan Mermelstein (Rho), Co-Founder, Vivid Racing
- Rob Rohn (Rho), Co-Founder, Vivid Racing
- J. Tylee Wilson (Delta-Beta), Chairman, RJR Nabisco
- Pierson M. Grieve (Epsilon-Delta), CEO, Ecolab, Inc
- John P. Surma, Jr. (Alpha-Delta), Chairman and CEO of US Steel
- Robert G. Krebs (Beta-Zeta), CEO, Burlington Northern/Santa Fe Railroad Corp.
- Paul Henson (Alpha-Psi), Chairman of the Board, United Telecom
- Jack Smith, Jr. (Gamma-Delta), President, General Motors
- Scottie Mayfield (Alpha-Tau), President, Mayfield Dairy Farms
Journalism
Academics
- Steven C. Beering (Chi), Former President, Purdue University
- Thomas J. Clifford (Delta-Mu), President, University of North Dakota
- Arthur H. DeRosier Jr. (Epsilon-Nu), Former President, Rocky Mountain College
- John G. Johnson (Delta-Alpha), President, Butler University
- Theron Montgomery Jr. (Alpha-Nu), President, Jacksonville State
- William N. Ruud (Delta-Mu), President, Shippensburg University
- John W. Ryan (Delta-Sigma), President Emeritus, Indiana University
- George J. Chedson (Delta-Sigma), Former President, Hope College
- William Cade (Tau), President, University of Lethbridge, behavioral ecologist
- Ralph Gallucci (Epsilon-Theta) Dept. Chair, Classics University of California, Santa Barbara
Science & Medicine
- Edgar Mitchell (Delta-Alpha), Astronaut on Apollo XIV
- John Covert Boyd (Zeta), designated by President Theodore Roosevelt to incorporate the American National Red Cross, one of original five members and founders of Kappa Sigma
- Dr. Charles Richardson (Zeta), Founder of the Chi Omega Fraternity for collegiate women.
- Denton Cooley, MD (Tau), Founder, Texas Heart Institute, performed first heart transplant in the United States
- Lee Berger (Kappa), Paleoanthropologist and National Geographic Explorer, awarded the First National Geographic Prize for Research and Exploration
- Edwin Hubble (Gamma-Beta), astronomer, namesake of Hubble Space Telescope
- Gen. Samuel C. Phillips (Delta-Gamma) University of Wyoming. NASA Apollo Program Director.
- Dr. Irvine W. Grote (Alpha-Iota) University of Tennessee Chattanooga. Noted Chemist and inventor of Rolaids.
Sports
- Bert Jones (Gamma), former Quarterback, Baltimore Colts (ret)
- Chris Festa (Epsilon-Sigma), Firestone Indy Light Series, #24 Car Alliance Motorsports Racing Team
- Dick Schafrath (Alpha-Sigma), 6-time Pro Bowler, Cleveland Browns and Ohio State Senator
- Curtis Strange (Delta-Omega), professional golfer
- Phil Hill (Delta-Eta), Formula 1 driver
- Rick Barry (Epsilon-Beta), NBA Hall of Fame
- Fisher DeBerry (Alpha-Nu), Head Football Coach, Air Force Academy
- James Kent Hull (Delta-Chi), Center, Buffalo Bills
- Lloyd Carr (Beta-Gamma), Former Head Football Coach, Michigan
- Jerry Jones (Xi), Owner, Dallas Cowboys
- Lamar Hunt (Delta-Pi), Owner, Kansas City Chiefs, Columbus Crew, Kansas City Wizards, and F.C. Dallas Founder of the American Football League, Co founder North American Soccer League, and Major League Soccer
- George J. Maloof, Jr. (Kappa-Alpha), co-owner of the Sacramento Kings, Sacramento Monarchs, and Palms Hotel and Casino.
- Brian Sipe (Epsilon-Iota), former MVP quarterback, Cleveland Browns
- Lanny Wadkins (Delta-Omega), Professional golfer (1995 Ryder Cup Team)
- George Huff (Alpha-Gamma), Manager of Illinois Baseball and the Boston Red Sox. Former University of Illinois basketball arena named for him (Huff Hall).
- Jay Haas (Delta-Omega), Professional golfer
- Peter Jacobsen (Gamma-Alpha), Professional golfer
- Carl Lundgren (Alpha-Gamma), Pitcher for the Chicago Cubs. On the mound for the first ever Tinkers to Evers to Chance double play.
- Charlie Monfort (Delta-Sigma), Owner of the Colorado Rockies
- Cam Cameron (Beta-Theta), Offensive Coordinator, Baltimore Ravens
- Brian Young (Epsilon-Xi), Starting Defensive Guard New Orleans Saints
- Steve Owens (Gamma-Kappa), 1969 Heisman Trophy Winner, Detroit Lions
- Bob Zuppke (Alpha-Gamma), Member of the College Football Hall of Fame and Innovator of the Huddle and Flea Flicker
- Greg Landry (Gamma-Delta), former Quarterback, Detroit Lions (ret)
- Ted Hendricks (Epsilon-Beta), Defensive End, Raiders, Hall of Fame
- Dan Dierdorf (Beta-Gamma), Offensive Lineman, St Louis Cardinals, Hall of Fame
- Cecil Upshaw Jr. (Epsilon), Pitcher, Atlanta Braves (ret)
- Richie Cunningham (Epsilon-Chi), Kicker, Dallas Cowboys
- Chuck Dobson (Gamma-Omicron), Pitcher, California Angels (ret)
- Rollie Massimino (Alpha-Lambda), Head Basketball Coach, Villanova University
- Erk Russell (Beta-Eta), Head Football coach, Georgia Southern
- Frank Pfeffer (Alpha-Gamma), Pitcher for the Chicago Cubs and Boston Braves. Recorded a No-Hitter against the Cincinnati Reds on 5/8/1907
- Tommy Casanova (Gamma), 4-time (1974-1977) Pro Bowl safety, Cincinnati Bengals
- Dick Conn (Beta-Lambda), Former NFL player for Pittsburgh Steelers and New England Patriots. Super Bowl winner
- Corey Hill (Theta-Psi), Professional Fighter for UFC
- Jimmye Laycock (Nu), Head football coach for the College of William & Mary Tribe
Military